Cognitive impairment

Disease9 papers4 findings

In human cohorts, higher peripheral naive B cell and natural killer cell counts reduce cognitive impairment risk, whilst ghrelin is associated with the condition. Reviews also link sarcopenia to human cognitive impairment.

Human trial1
Humans2
Animals4

Associations

Ghrelin

upin humans1

1 study

Ghrelin is associated with cognitive impairment in humans.
“Clinical analyses identified ghrelin as the factor most strongly associated with CI.”
Humans
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

Ghrelin →

Sarcopenia

upin humans1

1 study

Sarcopenia is associated with cognitive impairment in humans.
Review
Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation · Frontiers in endocrinology · 16 Sep 2026

Sarcopenia →

Naive B cell

downin humans1HR 0.92

1 study

Naive B cell lowers the risk of cognitive impairment in humans (HR = 0.92, 95% CI: 0.87-0.98).
Humansafter full covariate adjustmentperipheral bloodn = 4,464
Peripheral immune cell profiles predict cognitive decline in older adults · Age and ageing · 1 Sep 2026

Natural killer cell

downin humans1HR 0.92

1 study

Natural killer cell lowers the risk of cognitive impairment in humans (HR = 0.92, 95% CI: 0.86-0.98).
HumansCD56hi NK cells after full covariate adjustmentperipheral bloodn = 4,464
Peripheral immune cell profiles predict cognitive decline in older adults · Age and ageing · 1 Sep 2026

Latest

Covariance Eigenspace Provides Latent Attribution of Longitudinal Effects in Brain Age Gap

In silicoPreprintarXiv

3 h

AnimalsBrain agingYesterday

Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice

The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.

Food Science & Nutrition · Shi H et al.

Centenarians and oldest olds in Liguria - COOL: A multidisciplinary cohort study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and baseline cohort profile

HumansExperimental Gerontology

Yesterday

Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation

ReviewFrontiers in Endocrinology

Yesterday

HumansPreprintInflammaging1 Oct

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · Tan X et al.

AnimalsMitochondria1 Oct