Reframing Alzheimer's Disease Through a Redox-Metabolic Framework
Abstract · CC BY
Alzheimer's disease (AD) has been conceptualised as a proteinopathy driven by amyloid-β plaques and hyperphosphorylated tau neurofibrillary tangles.
- Chronic inflammation
- Deregulated nutrient-sensing
- Mitochondrial dysfunction
- Ferroptosis
- Insulin/IGF-1 signalling
- NRF2–KEAP1 antioxidant response
- Oxidative phosphorylation
- Oxidative stress and ROS signalling
- NFE2L2
- Alzheimer's disease
- Reactive oxygen species
- Homo sapiens
The paper
Reframing Alzheimer's Disease Through a Redox-Metabolic Framework
Velázquez De Castro-Bono A, Castro-Luna G, Guil-Guerrero JL
International Journal of Molecular Sciences · 17 Sep 2026