Type 2 diabetes
Disease9 papers6 findingsMeSH D003924
In human cohort data, epigenetic puberty increases the risk of type 2 diabetes. Reviews connect type 2 diabetes to mitochondrial dysfunction and cognitive function, whilst in silico work links the disease to CCL8 and MMP9 in peripheral blood mononuclear cells.
- Human trial2
- Humans2
Associations
5Mitochondrial dysfunction
upin humans2
2 studies
Mitochondrial dysfunction
upin humans2
Mitochondrial dysfunction is associated with type 2 diabetes in humans.
Review
Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies · Diabetes, metabolic syndrome and obesity : targets and therapy · 23 Sep 2026
Mitochondrial dysfunction is associated with type 2 diabetes in humans.
“Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incompletely understood, mechanisms driving pancreatic β-cell failure, chronic inflammation, insulin resistance and diabetic complications.”
Review
Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective · Biomedicines · 24 Aug 2026
Epigenetic puberty
upin humans1HR 1.12–1.19
1 study
Epigenetic puberty
upin humans1HR 1.12–1.19
Epigenetic puberty raises the risk of type 2 diabetes in humans (HRs, 1.12 to 1.19).
Humans10-year onset in GS10 yearsn = 18,676
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
MMP9
upin silico1
1 study
MMP9
upin silico1
Type 2 diabetes is associated with MMP9 in silico.
“the expression changes of CCL8 and MMP9 were independent of peripheral blood mononuclear cell (PBMC) subset frequencies after CIBERSORT adjustment.”
In silicoperipheral blood mononuclear cell
Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes · PeerJ · 22 Sep 2026
CCL8
upin silico1
1 study
CCL8
upin silico1
Type 2 diabetes is associated with CCL8 in silico.
“the expression changes of CCL8 and MMP9 were independent of peripheral blood mononuclear cell (PBMC) subset frequencies after CIBERSORT adjustment.”
In silicoperipheral blood mononuclear cell
Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes · PeerJ · 22 Sep 2026
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Type 2 diabetes is associated with cognitive function in humans.
Reviewmetabolic dysfunction
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies · Frontiers in molecular neuroscience · 15 Sep 2026
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Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.