Drosophila melanogaster

1. Hypomagnetic field activates oxidative phosphorylation in flies.

   Model organisms5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

2. Hypomagnetic field increases superoxide in flies.

   Model organisms5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

3. Hypomagnetic field improves physical function in flies.

   Model organismsin wild-type flies5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

4. Hypomagnetic field shortens lifespan in flies.

   Model organismsin wild-type flies5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

5. Hypomagnetic field impairs physical function in flies.

   Model organismsin Pink1- mutants5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

6. Hypomagnetic field extends lifespan in flies (20%).

   Model organismsin Pink1- mutants5 nT

   Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration · Aging · 23 Sep 2026

Hypomagnetic field →

1. Exercise shortens lifespan in flies (~67%).

   Model organismsat ZT6 (siesta time)motor stimulationfemales

   The circadian clock: an important factor modifying the effect of physical activity on the lifespan of Drosophila melanogaster · Acta neurobiologiae experimentalis · 14 Sep 2026

2. Exercise shortens lifespan in flies (~20%).

   Model organismsat ZT6 (siesta time)motor stimulationmales

   The circadian clock: an important factor modifying the effect of physical activity on the lifespan of Drosophila melanogaster · Acta neurobiologiae experimentalis · 14 Sep 2026

3. Exercise shortens lifespan in flies (~84%).

   Model organismsat ZT1 (morning activity peak)motor stimulationfemales

   The circadian clock: an important factor modifying the effect of physical activity on the lifespan of Drosophila melanogaster · Acta neurobiologiae experimentalis · 14 Sep 2026

4. Exercise extends lifespan in flies (~35%).

   Model organismsat ZT1 (morning activity peak)motor stimulationmales

   The circadian clock: an important factor modifying the effect of physical activity on the lifespan of Drosophila melanogaster · Acta neurobiologiae experimentalis · 14 Sep 2026

Exercise →

1. Denl/af9 knockdown increases NAD/NADH ratio in flies.

   Model organismspan-neuronal suppressionheadmales

   Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint

2. Denl/af9 knockdown increases ATP in flies.

   Model organismspan-neuronal suppressionheadmales

   Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint

3. Denl/af9 knockdown extends lifespan in flies.

   Reviewpan-neuronal suppressionneuron

   Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint

Denl/af9 knockdown →

1. Erastin decreases ferritin-bound iron in flies.

   Model organismsmales

   Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026

2. Erastin increases Fe2+/Fe3+ ratio in flies.

   Model organismsmales

   Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026

3. Erastin shortens lifespan in flies.

   Model organisms

   Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026

Erastin →

1. Social isolation shortens lifespan in flies.

   Model organismsin context of TDP-43 neurodegeneration

   Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint

2. Social isolation activates mdg4 in flies.

   Model organisms

   Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint

3. Social isolation increases neurodegeneration in flies.

   Model organismsin response to subsequent induction of pathological levels of TDP-43

   Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint

Social isolation →

1. Physalis pubescens polysaccharides decrease malondialdehyde in flies.

   Model organismsselenylated fruit polysaccharide derivativefemales

   Selenylated Physalis pubescens polysaccharide extends lifespan and activates Nrf2/HO-1-mediated antioxidant defense: structural elucidation and multi-target mechanism · Bioorganic chemistry · 23 Sep 2026

2. Physalis pubescens polysaccharides activate NRF2–KEAP1 antioxidant response in flies.

   Model organismsselenylated fruit polysaccharide derivativefemales

   Selenylated Physalis pubescens polysaccharide extends lifespan and activates Nrf2/HO-1-mediated antioxidant defense: structural elucidation and multi-target mechanism · Bioorganic chemistry · 23 Sep 2026

3. Physalis pubescens polysaccharides extend lifespan in flies.

   Model organismsselenylated fruit polysaccharide derivativefemales

   Selenylated Physalis pubescens polysaccharide extends lifespan and activates Nrf2/HO-1-mediated antioxidant defense: structural elucidation and multi-target mechanism · Bioorganic chemistry · 23 Sep 2026

Physalis pubescens polysaccharides →

1. Reducing ribosome abundance induces meiotic defects in flies.

   Model organismsoocytefemales

   Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes · bioRxiv · 30 Sep 2026 · Preprint

2. Reducing ribosome abundance impairs developmental competence in flies.

   Model organismsoocytefemales

   Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes · bioRxiv · 30 Sep 2026 · Preprint

Reducing ribosome abundance →

1. Rotenone impairs cognitive function in flies.

   Model organismsin APOE4 flies

   Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants · bioRxiv : the preprint server for biology · 12 Sep 2026 · Preprint

2. Rotenone shortens lifespan in flies.

   Model organismsin APOE4 flies

   Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants · bioRxiv : the preprint server for biology · 12 Sep 2026 · Preprint

Rotenone →

1. Social interaction increases Ddc in flies.

   Model organismsco-housing with young femalesco-housing with young femalesmales

   Social Interaction With Younger Females Extends Lifespan in Aged Male Drosophila melanogaster Independent of Vitamin C · Frontiers in bioscience (Elite edition) · 1 Sep 2026

2. Social interaction extends lifespan in flies.

   Model organismsco-housing with 1-3-day-old femalesco-housing with young femalesmales

   Social Interaction With Younger Females Extends Lifespan in Aged Male Drosophila melanogaster Independent of Vitamin C · Frontiers in bioscience (Elite edition) · 1 Sep 2026

Social interaction →

1. Tauwt pan-neuronal expression decreases Uch in flies.

   Model organismstransgenic fliespan-neuronal expressionneuron25 days

   Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease · Gene · 1 Oct 2026

Tauwt pan-neuronal expression →