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Cellular senescenceSenescent cells, the SASP, and the drugs that clear or quiet them.
Aging clocksEpigenetic, blood-based and other measures of biological age.
mTOR & rapamycinNutrient sensing through mTOR, and the rapalogs that dial it down.
Partial reprogrammingYamanaka factors, epigenetic reprogramming and cellular rejuvenation.
NAD+ & sirtuinsNAD+ precursors, sirtuins and the metabolism of aging cells.
MitochondriaMitochondrial function, mitophagy and energy decline with age.
Dietary restrictionCaloric restriction, fasting and time-restricted eating.
GLP-1 drugsSemaglutide, tirzepatide and what incretin drugs do to aging.
InflammagingChronic low-grade inflammation and the aging immune system.
Brain agingCognitive aging, neurodegeneration and the aging brain.

APOE

GeneHomo sapiens1 paperHGNC 613NCBI Gene 348Taxon 9606

Model organisms1

Latest

2

Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

Model organismsPreprintbioRxiv

·Yesterday

Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation

ReviewAging and Disease

·30 Sep

Related

Lipid and ceramide metabolism2
Altered intercellular communication1
Alzheimer's disease1
Autophagy1
Cellular senescence1
Chronic inflammation1
Disabled macroautophagy1
ER unfolded protein response1
GLaz1
Loss of proteostasis1
Mitochondrial biogenesis (PGC-1α)1
Mitochondrial dysfunction1
Oxidative stress and ROS signalling1
Apoe expression1
Neurodegenerative disease1
Obesogenic diet1

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