Erastin
Intervention2 papers3 findingsPubChem 11214940ChEBI 94287
- Animals1
- Model organisms1
Outcomes
3Ferritin-bound iron
downin flies1
1 study
Ferritin-bound iron
downin flies1
Erastin decreases ferritin-bound iron in flies.
Model organismsmales
Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026
Fe2+/Fe3+ ratio
upin flies1
1 study
Fe2+/Fe3+ ratio
upin flies1
Erastin increases Fe2+/Fe3+ ratio in flies.
Model organismsmales
Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026
Lifespan
downin flies1
1 study
Lifespan
downin flies1
Erastin shortens lifespan in flies.
Model organisms
Fruit flies provide an in vivo model to study ferroptosis and lifespan · Redox biology · 28 Sep 2026
Latest
2Fruit flies provide an in vivo model to study ferroptosis and lifespan
Ferroptosis-inducing compounds shortened fly lifespan in a diet-dependent manner, while antioxidant treatment restored longevity and reversed iron-related changes in males.
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.