Social isolation
Intervention1 paper3 findings
- Model organisms1
Outcomes
3Lifespan
downin flies1
1 study
Lifespan
downin flies1
Social isolation shortens lifespan in flies.
Model organismsin context of TDP-43 neurodegeneration
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint
mdg4
upin flies1
1 study
mdg4
upin flies1
Social isolation activates mdg4 in flies.
Model organisms
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint
Neurodegeneration
upin flies1
1 study
Neurodegeneration
upin flies1
Social isolation increases neurodegeneration in flies.
Model organismsin response to subsequent induction of pathological levels of TDP-43
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint
Latest
1Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.