Compound 991

Intervention1 paper4 findings

Model organisms1

Outcomes

2

Lifespan

upin fission yeast1upin flies1upin worms1

1 study

Compound 991 extends lifespan in fission yeast.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Compound 991 extends lifespan in worms.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Compound 991 extends lifespan in flies.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026

Pro-longevity proteomic profile

upin mice1

1 study

Compound 991 induces pro-longevity proteomic profile in mice.
Animals
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026

Pro-longevity proteomic profile →

Latest

1

Model organisms30 Sep

Direct AMPK activation extends lifespan across yeast, worms, and flies

Treatment with the direct activator 991 also induced a pro-longevity proteomic profile in mice.

Aging Cell · Dos Santos E et al.