Brain agingModel organismsPreprint2 Oct 2026

Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

bioRxiv

The paper

Biglari S, Yeragi E, Bamisaye D et al.

bioRxiv · 12 Sep 2026 · Preprint, not yet peer-reviewed

doi.org/10.64898/2026.09.08.750261 PubMed

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Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

The paper

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Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

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Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

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