Denl/af9 knockdown
Intervention1 paper3 findings
- Model organisms1
Outcomes
3NAD/NADH ratio
upin flies1
1 study
NAD/NADH ratio
upin flies1
Denl/af9 knockdown increases NAD/NADH ratio in flies.
Model organismspan-neuronal suppressionheadmales
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint
ATP
upin flies1
1 study
ATP
upin flies1
Denl/af9 knockdown increases ATP in flies.
Model organismspan-neuronal suppressionheadmales
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint
Lifespan
upin flies1
1 study
Lifespan
upin flies1
Denl/af9 knockdown extends lifespan in flies.
Reviewpan-neuronal suppressionneuron
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint
Latest
1Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.