AgingResearch.News

Apoptosis

Pathway27 papers8 findingsGO 0006915

In cell, mouse, and chicken studies, diverse interventions modulate apoptosis, with specific treatments inhibiting cell death across tissues while chemical stress induces it in human and mouse cells. Reviews link mitochondrial dysfunction and natural products to its regulation.

  • Animals10
  • Model organisms2
  • Cells2

Interventions

6

N-methyl-n-nitrosourea

upin human cells1upin mouse cells1

1 study
  1. N-methyl-n-nitrosourea induces apoptosis in mouse cells.

    Cellsmesenchymal stem cell

    Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

  2. N-methyl-n-nitrosourea induces apoptosis in human cells.

    Cellsmesenchymal stem cell

    Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

N-methyl-n-nitrosourea →

Natural products

downin reviews1

1 study
  1. Natural products inhibit apoptosis.

    Reviewvia Bcl-2/Bax/caspase signalingkidney

    The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms · Mini reviews in medicinal chemistry · 30 Sep 2026

Natural products →

Aging-resistant ionogel dressing

downin mice1

1 study
  1. Aging-resistant ionogel dressing inhibits apoptosis in mice.

    Animalssenescent microenvironmentskin

    A magnesium-phenolic hydrogel accelerates wound healing in aged mice · ACS applied materials & interfaces · 28 Sep 2026

Aging-resistant ionogel dressing →

MCC950

downin cells1

1 study
  1. MCC950 decreases apoptosis in cells.

    Cellsduring agingbone marrow-derived macrophages

    NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages · Bulletin of experimental biology and medicine · 28 Sep 2026

MCC950 →

Erigeron breviscapus

downin mice1

1 study
  1. Erigeron breviscapus inhibits apoptosis in mice.

    Animalsin SAMP8 mice

    Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice · Biogerontology · 25 Sep 2026

Erigeron breviscapus →

FOXO3 overexpression

downin chickens1

1 study
  1. FOXO3 overexpression decreases apoptosis in chickens.

    Animalsat 3 dphovaryfemales

    FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026

FOXO3 overexpression →

Upstream

1

Mitochondrial dysfunction

upin reviews1

1 study
  1. Mitochondrial dysfunction activates apoptosis.

    Review

    Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies · Ageing research reviews · 30 Sep 2026

Mitochondrial dysfunction →

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