Clonal hematopoiesis
Disease2 papers2 findings
- Cells1
Associations
2Cancer
upin humans1
1 study
Cancer
upin humans1
Clonal hematopoiesis is associated with cancer in humans.
Review
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Cardiovascular disease
upin humans1
1 study
Cardiovascular disease
upin humans1
Clonal hematopoiesis is associated with cardiovascular disease in humans.
Review
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Latest
9TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Persistent interferon-gamma fuels chronic cardiac remodeling after heart attacks in aged mice
A conserved interferon-gamma signature and heightened T cell recruitment drive worse long-term heart failure outcomes in older mice following myocardial infarction.
Clonal blood mutations in ASXL1 associate with higher lung cancer risk
Researchers analyzing two large human cohorts found that ASXL1-mutant clonal hematopoiesis linked to more than triple the risk of lung cancer in smokers.
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.