DNA methylation
Biomarker4 papers1 finding
- Humans2
- Model organisms1
- Cells1
Interventions
1DNMT3A mutation
downin human cells1
1 study
DNMT3A mutation
downin human cells1
DNMT3A mutation decreases DNA methylation in human cells.
Cellsmacrophage
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint
Latest
25Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.
Mammalian cellular identity erodes with age through predictable chromatin drift
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.