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Cells·Preprint
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
bioRxiv · 30 Sept · Grafton F, Rohani N, Lim WF et al.
Animals·Preprint
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
bioRxiv · 30 Sept · Lu YRR, Shen H, Kajderowicz K et al.
Cells·Peer-reviewed
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Nature communications · 31 Aug · Kim DW, Kwon EJ, Jeon BJ et al.
Humans·Peer-reviewed
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Nature immunology · 30 Sept · Aguilar-Navarro AG, Edun G, Gower M et al.
Model organisms·Preprint
A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.
bioRxiv · 30 Sept · Judson KL, Danielson KJ, Tang S et al.
