Dnmt3a
GeneMus musculus2 papersMGI 1261827NCBI Gene 13435Taxon 10090
- Animals1
- Cells1
Latest
2AnimalsPreprint
TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
CellsPreprint
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.