Telomere attrition
Hallmark of aging23 papers3 findings
- Humans9
- Animals2
- Model organisms2
- Cells2
Interventions
1Sonnerachromones a–c
downin worms1
1 study
Sonnerachromones a–c
downin worms1
Sonnerachromones a–c decreases telomere attrition in worms.
Model organisms
Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint
Effects
1DNA damage response
upin humans1
1 study
DNA damage response
upin humans1
Telomere attrition activates DNA damage response in humans.
Reviewwhen telomeres become critically short with aging
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Associations
1Gulf war oil fire pollutants
upin humans1
1 study
Gulf war oil fire pollutants
upin humans1
Gulf war oil fire pollutants are associated with telomere attrition in humans.
“The patient's Gulf War exposure to oil fire pollutants (benzene, toluene, PAHs, lead, cadmium, and particulate matter) likely contributed to telomere shortening and TSD-related multisystem disease.”
Humansin a Gulf War veteranbenzene, toluene, PAHs, lead, cadmium, and particulate mattermalesn = 1
A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder · Journal of clinical medicine · 11 Sep 2026
Latest
23Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Telomere attrition marks disease severity in chronic cholestatic liver diseases
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.
Biological aging clocks combined with genetics improve dementia risk prediction
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.