Tet2
GeneMus musculus2 papers1 findingMGI 2443298NCBI Gene 214133Taxon 10090
- Humans1
- Animals1
Effects
1Physical function
downin mice1
1 study
Physical function
downin mice1
Tet2 impairs physical function in mice.
Animalsmouse model
Somatic blood mutations associate with accelerated frailty and functional decline in humans · medRxiv · 1 Oct 2026 · Preprint
Latest
2AnimalsPreprint
TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.