DNMT3A
GeneHomo sapiens1 paperHGNC 2978NCBI Gene 1788Taxon 9606
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2ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
CellsPreprint
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.