Histone modification and chromatin remodelling
Pathway13 papers1 finding
- Human trial1
- Animals1
- Model organisms3
- Cells5
- In silico1
Associations
1DNA methylation
upin Mammalia1
1 study
DNA methylation
upin Mammalia1
DNA methylation is associated with histone modification and chromatin remodelling in Mammalia.
Reviewat PRC2-bound low-methylated regions in somatic mitotic tissuessomatic mitotic tissues
Mammalian cellular identity erodes with age through predictable chromatin drift · Nature · 30 Sep 2026
Latest
13Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
Mammalian cellular identity erodes with age through predictable chromatin drift
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate
Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.
Raising H3K9 methylation curbs leukemic stem cell proliferation
Targeting this epigenetic modification in mouse models and patient samples reduces leukemogenesis in young and aged cells.
Targeted metal modulation preserves retinal structure and vision in zebrafish
Telomir-Zn depleted labile iron, lowered oxidative stress, and improved visual behaviors and epigenetic marks in zebrafish and cultured human retinal cells.