Cancer
Disease18 papers3 findings
Reviews link clonal haematopoiesis and epigenetic alterations to human cancer risk, while one in silico study suggests p53-dependent LAMTOR3 protects against the disease.
- Humans4
- Cells2
Upstream
1LAMTOR3
downin silico1
1 study
LAMTOR3
downin silico1
LAMTOR3 protects against cancer in silico.
In silicop53-dependent
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026
Associations
2Clonal hematopoiesis
upin humans1
1 study
Clonal hematopoiesis
upin humans1
Clonal hematopoiesis is associated with cancer in humans.
Review
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Epigenetic alterations
upin humans1
1 study
Epigenetic alterations
upin humans1
Epigenetic alterations raise the risk of cancer in humans.
“Age-related epigenetic alterations can promote cancer, which exploits plasticity for evolution, immune evasion, metastasis, and resistance.”
Review
The Epigenetic Aging-Cancer Continuum: Biomarkers, Metabolism, and Therapy · Genes · 16 Sep 2026
Latest
43Rank normalization resolves distinct proteome degradation pathways in cultured cells
A percentile-based normalization method reveals substrate preferences between proteasomal and lysosomal clearance systems in cultured cells.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
Fruit flies provide an in vivo model to study ferroptosis and lifespan
Ferroptosis-inducing compounds shortened fly lifespan in a diet-dependent manner, while antioxidant treatment restored longevity and reversed iron-related changes in males.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.