Ubiquitin–proteasome system
Pathway21 papers5 findingsGO 0043161
In silico analyses link the ubiquitin–proteasome system to Alzheimer's disease and loss of proteostasis in vulnerable brain regions. Cell studies show BAG3 knockout reduces its activity in human astrocytes, while Fbxl21 mediates it in mouse cells.
- Humans1
- Animals6
- Model organisms1
- Cells5
Interventions
1BAG3 knockout
downin human cells1
1 study
BAG3 knockout
downin human cells1
BAG3 knockout decreases ubiquitin–proteasome system in human cells.
Cellsin BAG3-deficient astrocytesCRISPR/Cas9 editingastrocyte
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026
Upstream
2Fbxl21
mediatesin mouse cells1
1 study
Fbxl21
mediatesin mouse cells1
Fbxl21 mediates ubiquitin–proteasome system in mouse cells.
Cells
Circadian E3 ligase FBXL21 regulates daily muscle proteostasis by targeting DNAJB6 · EMBO reports · 30 Sep 2026
SNCA
downin humans1
1 study
SNCA
downin humans1
SNCA impairs ubiquitin–proteasome system in humans.
“pathogenic α-synuclein species interact with and impair 20S/26S proteasomes, affecting proteolytic activity, subunit composition, and complex assembly”
Reviewpathogenic species
Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system · Frontiers in cell and developmental biology · 10 Sep 2026
Associations
2Loss of proteostasis
upin silico1
1 study
Loss of proteostasis
upin silico1
Ubiquitin–proteasome system is associated with loss of proteostasis in silico.
In silicoin AD brain transcriptomicsbrain
A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026
Alzheimer's disease
downin silico1
1 study
Alzheimer's disease
downin silico1
Alzheimer's disease is associated with ubiquitin–proteasome system in silico.
In silicoin vulnerable brain regionsbrain
A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026
Latest
21Rank normalization resolves distinct proteome degradation pathways in cultured cells
A percentile-based normalization method reveals substrate preferences between proteasomal and lysosomal clearance systems in cultured cells.
Circadian E3 ligase FBXL21 regulates daily muscle proteostasis by targeting DNAJB6
Loss of FBXL21 disrupts client protein degradation, worsening stress responses in muscle cells and mutant mice.