MAPT
GeneHomo sapiens6 papers1 findingHGNC 6893NCBI Gene 4137Taxon 9606
- Model organisms1
- Cells4
Interventions
1Mtdna depletion
upin human cells1
1 study
Mtdna depletion
upin human cells1
Mtdna depletion increases MAPT in human cells.
Cellschronic mtDNA depletion (rho0)SH-SY5Y
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026
Latest
13Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
CellsBrain aging
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.