Brain agingReview26 Sep 2026

Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system

Frontiers in Cell and Developmental Biology

Abstract · CC BY

Aging is the major risk factor for synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. However, the molecular mechanisms linking aging to. α-Synuclein cytotoxicity remain incompletely understood.

The paper

Ali TT, Popova B, Braus GH

Frontiers in Cell and Developmental Biology · 10 Sep 2026

doi.org/10.3389/fcell.2026.1906331 PubMed

See all

HumansPreprintYesterday

Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.

bioRxiv · Caglayan E et al.

AnimalsPreprint29 Sep

CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.

bioRxiv · Harris AS et al.

AnimalsPreprintYesterday

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.

bioRxiv · R. Carvalho D et al.

CellsPreprintYesterday

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.

bioRxiv · Alsolami S et al.

HumansPreprintYesterday

Auditory nerve myelin degeneration defines a subtype of age-related hearing loss

Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.

medRxiv · Harris KC et al.

Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system

The paper

More on Brain aging

Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

Auditory nerve myelin degeneration defines a subtype of age-related hearing loss