SNCA
GeneHomo sapiens9 papers7 findingsHGNC 11138NCBI Gene 6622Taxon 9606
Reviews link SNCA to Parkinson's disease and impairment of the ubiquitin–proteasome system in humans. In worms, it reduces triacylglycerols and increases long-chain unsaturated fatty acids, while the herbal formula Xiaoyao san decreases its levels.
- Humans1
- Animals1
- Model organisms2
- Cells2
Interventions
1Xiaoyao san
downin worms1
1 study
Xiaoyao san
downin worms1
Xiaoyao san decreases SNCA in worms.
Model organisms
[Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026
Effects
3Long-chain unsaturated fatty acids
upin worms1
1 study
Long-chain unsaturated fatty acids
upin worms1
SNCA increases long-chain unsaturated fatty acids in worms.
Model organisms
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes · EMBO reports · 29 Sep 2026
Triacylglycerols
downin worms1
1 study
Triacylglycerols
downin worms1
SNCA decreases triacylglycerols in worms.
Model organisms
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes · EMBO reports · 29 Sep 2026
Ubiquitin–proteasome system
downin humans1
1 study
Ubiquitin–proteasome system
downin humans1
SNCA impairs ubiquitin–proteasome system in humans.
“pathogenic α-synuclein species interact with and impair 20S/26S proteasomes, affecting proteolytic activity, subunit composition, and complex assembly”
Reviewpathogenic species
Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system · Frontiers in cell and developmental biology · 10 Sep 2026
Associations
1Parkinson's disease
upin humans3
3 studies
Parkinson's disease
upin humans3
SNCA is associated with Parkinson's disease in humans.
Review
Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
SNCA is associated with Parkinson's disease in humans.
Reviewneuron
Cellular and systemic modifiers of alpha-synuclein proteostasis · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
SNCA is associated with Parkinson's disease in humans.
Review
Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets · Metabolic brain disease · 28 Sep 2026
Latest
17Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.