Heat shock response and chaperones
Pathway8 papers3 findings
- Animals1
- Model organisms3
- In silico1
Interventions
1Turnera diffusa polysaccharides
upin model organisms1
1 study
Turnera diffusa polysaccharides
upin model organisms1
Turnera diffusa polysaccharides activate heat shock response and chaperones.
Model organisms
Turnera diffusa polysaccharides promote healthy aging through conserved stress response regulation and metabolic remodeling across multiple aging models · Biogerontology · 25 Sep 2026
Effects
1Loss of proteostasis
downin reviews1
1 study
Loss of proteostasis
downin reviews1
Heat shock response and chaperones decrease loss of proteostasis.
Reviewcytosol/nucleus
More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Upstream
1HSF1
upin reviews1
1 study
HSF1
upin reviews1
HSF1 activates heat shock response and chaperones.
Reviewduring loss of proteostasis in the cytosol/nucleuscytosol/nucleus
More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Latest
8Nematode heat-shock protein HSP-12.6 selectively protects muscle thick filaments in vivo
The chaperone regulates lifespan in Caenorhabditis elegans and specifically shields myosin-containing structures without interacting with thin filaments or polyQ aggregates.
Circadian E3 ligase FBXL21 regulates daily muscle proteostasis by targeting DNAJB6
Loss of FBXL21 disrupts client protein degradation, worsening stress responses in muscle cells and mutant mice.