TP53
GeneHomo sapiens6 papersHGNC 11998NCBI Gene 7157Taxon 9606
- Animals2
- Cells3
Latest
9AnimalsCellular senescence
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
CellsMitochondria
FUNDC1 protects skin against UVA damage through mitophagy and P53 stability
Researchers identified a molecular pathway where FUNDC1 preserves mitochondrial quality and works with BAZ1B to regulate P53 during skin photoaging.
Cells
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling
Unlike human and mouse cells, blind mole-rat stem cells maintained viability and differentiation after carcinogen exposure by preserving protective gene pathways.