NLRP3 inflammasome
Pathway15 papers6 findings
In mice, the NLRP3 inflammasome is activated by faecal microbiota transplantation and AGTR2 knockout, but inhibited by icariin. In aging macrophage cells, it increases DNA fragmentation, whilst reviews link it to human lifespan and vessel-wall OLR1 activation.
- Humans1
- Animals5
- Cells1
Interventions
3Icariin
downin mice1
1 study
Icariin
downin mice1
Icariin inhibits NLRP3 inflammasome in mice.
Animals
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026
Fecal microbiota transplantation
upin mice1
1 study
Fecal microbiota transplantation
upin mice1
Fecal microbiota transplantation activates NLRP3 inflammasome in mice.
Animalsdonor with ARHLgut microbiota of ARHL patientsspiral ligament
Gut microbes from hearing loss patients trigger inner ear damage in young mice · Research Square · 30 Sep 2026 · Preprint
AGTR2 knockout
upin mice1
1 study
AGTR2 knockout
upin mice1
AGTR2 knockout activates NLRP3 inflammasome in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Effects
1DNA fragmentation
upin cells1
1 study
DNA fragmentation
upin cells1
NLRP3 inflammasome increases DNA fragmentation in cells.
Cellsduring agingbone marrow-derived macrophages
NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages · Bulletin of experimental biology and medicine · 28 Sep 2026
Upstream
1OLR1
upin humans1
1 study
OLR1
upin humans1
OLR1 activates NLRP3 inflammasome in humans.
Reviewvessel wall
An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis · Current atherosclerosis reports · 29 Sep 2026
Associations
1Lifespan
downin humans1
1 study
Lifespan
downin humans1
NLRP3 inflammasome is associated with lifespan in humans.
“Exceptional longevity also appears to depend on limiting the detrimental consequences of chronic inflammation through delayed or better-controlled inflammaging, restrained NLRP3 inflammasome activation and preserved capacity to buffer oxidative stress.”
Reviewexceptional longevity
Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians · International journal of molecular sciences · 21 Sep 2026
Latest
15ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice
Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice
The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.
Dual cognitive and motor training improves cognitive function in aging rats
The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.
NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages
Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.