mTOR signalling
Pathway21 papers5 findingsGO 0031929
Studies in mice and animals show that rapamycin, Cedrus deodara flavonoids, and Arc-engineered exosomes inhibit mTOR signalling. In addition, reviews describe inhibition of this pathway by rapamycin and intermittent fasting.
- Animals8
- Model organisms3
- Cells1
Interventions
4Rapamycin
downin mice1downin reviews1
2 studies
Rapamycin
downin mice1downin reviews1
Rapamycin inhibits mTOR signalling.
Review
Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiers · Biochimica et biophysica acta. General subjects · 24 Sep 2026
Rapamycin inhibits mTOR signalling in mice.
Animalsin chemoresistant lung cancertumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
Cedrus deodara flavonoids
downin mice1
1 study
Cedrus deodara flavonoids
downin mice1
Cedrus deodara flavonoids inhibit mTOR signalling in mice.
Animalsozone exposuredeep eutectic solvent extract14 days
Green Extraction of Flavonoids from Cedrus deodara Pollen with Deep Eutectic Solvents and Their Potential Anti-Senescence Properties · Research Square · 29 Sep 2026 · Preprint
Arc-engineered exosomes
downin animals1
1 study
Arc-engineered exosomes
downin animals1
Arc-engineered exosomes inhibit mTOR signalling.
Animalsneural stem cell-derived exosomes overexpressing Arc
Intranasal Arc-engineered exosomes reduce Alzheimer pathology by restoring autophagy · Nanomedicine : nanotechnology, biology, and medicine · 25 Sep 2026
Intermittent fasting
downin reviews1
1 study
Intermittent fasting
downin reviews1
Intermittent fasting inhibits mTOR signalling.
Review
Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges · Frontiers in nutrition · 15 Sep 2026
Latest
22Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer
The formulation co-delivers rapamycin and doxorubicin across the mucus barrier to inhibit mTOR and suppress tumor growth without evident systemic toxicity.
Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice
The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.