InflammagingReview28 Sep 2026

Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians

International Journal of Molecular Sciences

Abstract · CC BY

Centenarians, semi-supercentenarians and supercentenarians (i.e., oldest centenarians) display complex and heterogeneous immune remodelling. In this setting, immune attrition, memory, cytotoxic defence, inflammatory regulation and tissue surveillance remain sufficiently balanced to support survival with relatively preserved health.

The paper

Caruso C, Accardi G, Aiello A et al.

International Journal of Molecular Sciences · 21 Sep 2026

doi.org/10.3390/ijms27188420 PubMed

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Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians

The paper

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