DNA fragmentation

Biomarker1 paper1 finding

Cells1

Upstream

1

NLRP3 inflammasome

upin cells1

1 study

NLRP3 inflammasome increases DNA fragmentation in cells.
Cellsduring agingbone marrow-derived macrophages
NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages · Bulletin of experimental biology and medicine · 28 Sep 2026

NLRP3 inflammasome →

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CellsInflammaging29 Sep

NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages

Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.

Bulletin of Experimental Biology and Medicine · Blagova AV et al.