AGTR2 knockout
Intervention1 paper6 findings
- Animals1
Outcomes
6Genomic instability
upin mice1
1 study
Genomic instability
upin mice1
AGTR2 knockout induces genomic instability in mice.
Animals
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
NLRP3 inflammasome
upin mice1
1 study
NLRP3 inflammasome
upin mice1
AGTR2 knockout activates NLRP3 inflammasome in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
AGTR2 knockout induces cellular senescence in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Fibrosis
upin mice1
1 study
Fibrosis
upin mice1
AGTR2 knockout increases fibrosis in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Cardiac function
downin mice1
1 study
Cardiac function
downin mice1
AGTR2 knockout impairs cardiac function in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Lifespan
downin mice1
1 study
Lifespan
downin mice1
AGTR2 knockout shortens lifespan in mice (-5 months).
Animals
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Latest
1Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.