TNF
GeneHomo sapiens9 papers1 findingHGNC 11892NCBI Gene 7124Taxon 9606
- Human trial1
- Humans1
- Cells4
Effects
1Fibro-adipogenic progenitor
downin human cells1
1 study
Fibro-adipogenic progenitor
downin human cells1
TNF decreases fibro-adipogenic progenitor in human cells.
Cellsex vivo treatment
Resistance exercise shifts muscle progenitor cells to support growth in older adults · bioRxiv · 28 Sep 2026 · Preprint
Latest
10Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Resistance exercise shifts muscle progenitor cells to support growth in older adults
Blood flow restricted resistance training expands pro-myogenic fibro-adipogenic progenitors and inflammatory macrophages during muscle hypertrophy in older individuals.