Epigenetic puberty
Biomarker1 paper5 findings
- Humans1
Associations
4Mortality
upin humans1HR 1.12
1 study
Mortality
upin humans1HR 1.12
Epigenetic puberty predicts mortality in humans (HR, 1.12).
Humansin GSfemalesn = 10,974
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Epigenetic puberty predicts mortality in humans (ORs, 1.39 and 1.46).
Humansin HRSn = 3,642
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Multimorbidity
upin humans1
1 study
Multimorbidity
upin humans1
Epigenetic puberty is associated with multimorbidity in humans (standardized coefficients, 0.10 to 0.16).
Humansin HRSfemalesn = 2,106
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Type 2 diabetes
upin humans1HR 1.12–1.19
1 study
Type 2 diabetes
upin humans1HR 1.12–1.19
Epigenetic puberty raises the risk of type 2 diabetes in humans (HRs, 1.12 to 1.19).
Humans10-year onset in GS10 yearsn = 18,676
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Epigenetic clocks
upin humans1HR 0.13–0.47
1 study
Epigenetic clocks
upin humans1HR 0.13–0.47
Epigenetic puberty is associated with epigenetic clocks in humans (standardized coefficients: HRS, 0.13 to 0.47; GS, 0.05 to 0.40).
Humansage-residualized
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Latest
1Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.