Sarcopenia as a manifestation of systemic energetic failure with ageing
Ferrucci L, Donega S, Picca A et al.
The Lancet. Healthy Longevity · 28 Sep 2026
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.
