JAK–STAT signalling
Pathway7 papers1 findingGO 0007259
- Animals3
- Cells1
- In silico1
Interventions
1M2-KC-FEV
upin mouse cells1
1 study
M2-KC-FEV
upin mouse cells1
M2-KC-FEV activates JAK–STAT signalling in mouse cells.
Cells
Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026
Latest
7Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice
Blocking the cytokine with secukinumab reduced cartilage senescence and slowed osteoarthritis progression in a mouse model.
Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging
Vesicles fused from M2 macrophages and keratinocytes reduced oxidative stress, inflammation, and collagen degradation through the IL-4Rα/JAK/STAT3 pathway.
Long-term human skin platform models chronic inflammation and senolytic treatments
The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.