ER unfolded protein response
Pathway8 papers1 findingGO 0030968
- Animals1
- Cells2
Interventions
1Tardbp G376D mutation
upin human cells1
1 study
Tardbp G376D mutation
upin human cells1
Tardbp G376D mutation activates ER unfolded protein response in human cells.
“In parallel, activation of the Endoplasmic Reticulum UPR (UPR ER ) was observed, indicating a coordinated engagement of cellular stress pathways.”
Cellsdermal fibroblast
Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43G376D ALS Patient-Derived Fibroblasts · Antioxidants (Basel, Switzerland) · 22 Aug 2026
Latest
8CellsCellular senescence
Loss of PP4 drives airway senescence through endoplasmic reticulum stress
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
AnimalsCellular senescence
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.