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Animals·Peer-reviewed
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
Nature aging · 29 Sept · Finger F, Frost M, Watanabe S et al.
Animals·Preprint
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
bioRxiv · 27 Sept · Shemtov SJ, Hwang E, Chung CS et al.
Animals·Peer-reviewed
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.
Animals·Peer-reviewed
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.
Aging cell · 1 Oct · Yang K, Jian Y, Pang F et al.
Animals·Peer-reviewed
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
Cell reports · 30 Sept · Matsumoto S, Seo H, Taketomi Y et al.
