Akt1
GeneMus musculus4 papersMGI 87986NCBI Gene 11651Taxon 10090
- Animals4
Latest
5Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
AnimalsCellular senescence
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.
AnimalsCellular senescence
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.