Apoe
GeneMus musculus5 papers1 findingMGI 88057NCBI Gene 11816Taxon 10090
- Animals5
Effects
1Retinal degeneration
downin mice1
1 study
Retinal degeneration
downin mice1
Apoe protects against retinal degeneration in mice.
Animalsvia oxidized lipid cargo disposal to subretinal microglianeural retina
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint
Latest
5Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.