skn-1

1. Perilla frutescens activate skn-1 in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

Perilla frutescens →

1. skn-1 is required for lifespan in worms.

   “its beneficial effects on lifespan extension and collagen synthesis are SKN-1-dependent, as these effects are abolished in skn-1 mutants.”

   Model organismsfor pimozide-induced lifespan extension

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

1. skn-1 is required for sod-3 in worms.

   Model organismsfor XYS restorative effect on sod-3::GFP fluorescence

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

sod-3 →

1. klf-1 is required for skn-1 in worms.

   Model organismsactivation of SKN-1A and SKN-1C

   Krüppel-like factors modulate SKN-1 activity and lipid balance to control worm lifespan · Genetics · 29 Sep 2026

klf-1 →