NAD+ metabolism
Pathway11 papersGO 0019674
- Animals1
- Model organisms1
- Cells2
Latest
11Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
AnimalsNAD+ & sirtuins
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.