Cellular senescenceReview30 Sep 2026

Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications

Journal of Hematology & Oncology

The paper

Du L, Zhang Y, Liang R et al.

Journal of Hematology & Oncology · 29 Sep 2026

doi.org/10.1186/s13045-026-01847-x PubMed

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Human trialYesterday

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature Metabolism · Koning M et al.

AnimalsPreprint29 Sep

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.

bioRxiv · Torres G et al.

HumansPreprintYesterday

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · Simpson DJ et al.

Animals29 Sep

Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.

Aging Cell · Deng J et al.

Human trial26 Sep

A deep learning score for cellular senescence predicts human mortality and disease risk

The proteomic biomarker tracked chronic illness risk in the UK Biobank and shifted following an 18-month multimodal exercise intervention.

Aging Cell · Zhao S et al.

Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications

The paper

More on Cellular senescence

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

DNA methylation proxies of senescence markers track human disease and mortality

Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

A deep learning score for cellular senescence predicts human mortality and disease risk