Cellular senescenceReview30 Sep 2026

Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies

Frontiers in Bioscience

The paper

He W, Liu P, Kong J et al.

Frontiers in Bioscience · 1 Aug 2026

doi.org/10.31083/fbl48959 PubMed

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Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature Metabolism · Koning M et al.

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A distinct p21-driven macrophage senotype accumulates during aging and liver disease

Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.

bioRxiv · Torres G et al.

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DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · Simpson DJ et al.

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Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.

Aging Cell · Deng J et al.

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A deep learning score for cellular senescence predicts human mortality and disease risk

The proteomic biomarker tracked chronic illness risk in the UK Biobank and shifted following an 18-month multimodal exercise intervention.

Aging Cell · Zhao S et al.

Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies

The paper

More on Cellular senescence

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

DNA methylation proxies of senescence markers track human disease and mortality

Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

A deep learning score for cellular senescence predicts human mortality and disease risk