Synucleinopathies

Disease4 papers1 findingMeSH D000080874

Model organisms1

Upstream

1

Loss of proteostasis

mediatesin humans1

1 study

Loss of proteostasis mediates synucleinopathies in humans.
Reviewdepending on clearance capacity of diverse aggregates
Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

Loss of proteostasis →

Latest

5

Cellular and systemic modifiers of alpha-synuclein proteostasis

ReviewPhilosophical Transactions of the Royal Society of London. Series B, Biological Sciences

1 Oct

Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies

ReviewPhilosophical Transactions of the Royal Society of London. Series B, Biological Sciences

1 Oct

Model organismsBrain aging30 Sep

Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes

Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.

EMBO Reports · Zhang T et al.

Preliminary insights into whole-blood mitochondrial DNA copy number and telomere length in Parkinson's disease and multiple system atrophy

HumansJournal of Neurology

30 Sep

Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system

ReviewFrontiers in Cell and Developmental Biology

26 Sep