Neurodegenerative disease
Disease8 papers
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37CellsPreprint
Rank normalization resolves distinct proteome degradation pathways in cultured cells
A percentile-based normalization method reveals substrate preferences between proteasomal and lysosomal clearance systems in cultured cells.
Human neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.