Osteoporosis

1. Betaine decreases osteoporosis in rats.

   Animalsovariectomized rat models of osteoporosisBZ@Exosfemales

   Bone-targeted exosomes delivering betaine reverse bone loss in osteoporotic rats · Advanced materials (Deerfield Beach, Fla.) · 27 Sep 2026

Betaine →

1. Nuciferine protects against osteoporosis in rats.

   “Nuciferine significantly increased bone mineral density (BMD) and improved bone microarchitecture in OVX rats”

   Animalsovariectomybone12 weeksfemales

   Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy · Biomolecules · 21 Sep 2026

Nuciferine →

1. Osteoporosis decreases inflammatory macrophages in silico.

   In silicoin osteoarthritis combined with osteoporosissynoviumn = 23

   Single-cell transcriptomic analysis reveals macrophage state remodeling and attenuated ferro-aging-related features in osteoarthritis with osteoporosis · Research Square · 25 Sep 2026 · Preprint

1. Osteoporosis is associated with type H vessel.

   “Age-related osteoporosis is characterized by the simultaneous loss of bone mass and the regression of CD31 hi Emcn hi (Type H) vessels”

   Reviewage-relatedbone

   Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives · International journal of molecular sciences · 15 Sep 2026

1. Epigenetic age acceleration predicts osteoporosis in humans (hazard ratios of 1.29-3.17 per standard deviation).

   “In 1087 twins, epigenetic age acceleration predicted fracture and osteoporosis risk, with hazard ratios of 1.29-3.17 per standard deviation”

   Reviewin twinsn = 1,087

   Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity · Biomedicines · 2 Sep 2026

Epigenetic age acceleration →