ReviewPeer-reviewed

Future directions of osteoanabolic therapies in osteoporosis: Integrating current anabolic agents and emerging senescence-targeted strategies

Best practice & research. Clinical rheumatology · 1 Oct · Brooks HW, Cusick NC, Wu S et al.

The paper

Brooks HW, Cusick NC, Wu S et al.

Best practice & research. Clinical rheumatology

doi.org/10.1016/j.berh.2026.102203

Our read

Relevance: Core geroscience
Newsworthiness: Routine
Evidence: Review
Status: Peer-reviewed
Topic: Cellular senescence

Human trialPeer-reviewed

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.

Cellular senescence

HumansPreprint

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.

Cellular senescence

AnimalsPreprint

Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice

Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.

bioRxiv · 30 Sept · Shabanian K, Shabanian T, Da Dalt L et al.

Cellular senescence

AnimalsPeer-reviewed

Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models

Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.

Chinese journal of natural medicines · 1 Oct · Wang Y, Yin G, Niu M et al.

Cellular senescence

AnimalsPeer-reviewed

Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis

Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.

Biochimica et biophysica acta. General subjects · 30 Sept · Xu J, Yang J, Sun W et al.

Cellular senescence