Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives
Abstract · CC BY
Age-related osteoporosis is characterized by the simultaneous loss of bone mass and the regression of CD31 hi Emcn hi (Type H) vessels, a specialized capillary subtype that functionally couples angiogenesis with osteogenesis.
- Altered intercellular communication
- Cellular senescence
- Senescence-associated secretory phenotype (SASP)
- EMCN
- PECAM1
- Osteoporosis
The paper
Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives
Zhang J, Wei X, Han N
International Journal of Molecular Sciences · 15 Sep 2026