Epigenetic age acceleration
Biomarker2 papers3 findings
In humans, blood cell composition associates with epigenetic age acceleration. Reviews link epigenetic age acceleration to osteoporosis and bone fracture in human twins.
- Humans1
Associations
3Blood cell
mixedin humans1
1 study
Blood cell
mixedin humans1
Blood cell is associated with epigenetic age acceleration in humans (up to 21% variance explained).
Humansbloodn = 4,058
Blood cell composition explains substantial variation in DNA methylation age · Genome medicine · 2 Oct 2026
Osteoporosis
upin humans1
1 study
Osteoporosis
upin humans1
Epigenetic age acceleration predicts osteoporosis in humans (hazard ratios of 1.29-3.17 per standard deviation).
“In 1087 twins, epigenetic age acceleration predicted fracture and osteoporosis risk, with hazard ratios of 1.29-3.17 per standard deviation”
Reviewin twinsn = 1,087
Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity · Biomedicines · 2 Sep 2026
Bone fracture
upin humans1
1 study
Bone fracture
upin humans1
Epigenetic age acceleration predicts bone fracture in humans (hazard ratios of 1.29-3.17 per standard deviation).
“In 1087 twins, epigenetic age acceleration predicted fracture and osteoporosis risk, with hazard ratios of 1.29-3.17 per standard deviation”
Reviewin twinsn = 1,087
Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity · Biomedicines · 2 Sep 2026
Latest
7Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Telomere attrition marks disease severity in chronic cholestatic liver diseases
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.
Accelerated epigenetic aging predicts major depression and brain changes after trauma
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.