InflammagingHumansPreprint26 Sep 2026

Single-cell transcriptomic analysis reveals macrophage state remodeling and attenuated ferro-aging-related features in osteoarthritis with osteoporosis

Research Square

The paper

Huang S, Wei Z, Yu B et al.

Research Square · 25 Sep 2026 · Preprint, not yet peer-reviewed

doi.org/10.21203/rs.3.rs-10999132/v1 Europe PMC

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Human trial1 Oct

Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate

Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.

Science Translational Medicine · Lu Z et al.

HumansPreprintYesterday

Somatic blood mutations associate with accelerated frailty and functional decline in humans

In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.

medRxiv · Zhao K et al.

HumansPreprint1 Oct

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · Tan X et al.

HumansPreprint1 Oct

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.

medRxiv · Small A et al.

AnimalsYesterday

Loss of SATB1 alters 3D genome architecture in aged mouse T cells

Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.

Science Advances · Wang B et al.

Single-cell transcriptomic analysis reveals macrophage state remodeling and attenuated ferro-aging-related features in osteoarthritis with osteoporosis

The paper

More on Inflammaging

Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate

Somatic blood mutations associate with accelerated frailty and functional decline in humans

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Loss of SATB1 alters 3D genome architecture in aged mouse T cells